导师姓名：陈 立

职  称：教授、博士生导师

研究方向：慢性病护理学

单  位：4556银河国际在线/院长

单  位：4556银河国际在线基础医学院药理学系/主任

招生名额：硕士研究生3-4名

    陈立教授于2004年作为引进人才回国，被4556银河国际在线评为特聘教授及博士生导师，2014年9月任4556银河国际在线院长,并任基础医学院药理教研室主任及学术带头人,博士生导师。目前为 “吉林省护理与康复工程实验室”、“吉林省卫生厅护理重点实验室”、“吉林省纳米医学工程实验室”、“吉林省新药临床前药理评价科技创新中心”等多个实验平台和实验室主任，吉林省高等学校“护理学品牌专业建设点”负责人，吉林省“护理复合型人才培养模式创新实验区”负责人，中华护理学会理事，吉林省护理学会教育分会主任委员，长春市护理学会教育分会主任委员，中国药理学会常务理事，吉林省药理学会理事长。曾获得吉林省学科领军教授、宝钢优秀教师、吉林省优秀海外归国人才学术贡献奖、长春市第六批有突出贡献专家、4556银河国际在线“三育人”等荣誉称号。近5年主编国家级教材3部，副主编2部，参编教材12部，一部主编教材获得中国大学出版社图书优秀教材二等奖。承担国家级项目5项，省部级项目10余项，横向项目7项，累计经费1200余万元，获得吉林省自然科学二等奖一项、中国大学出版社图书优秀教材二等奖一项、吉林省高等学校教育技术成果三等奖一项、国家发明专利三项。发表论文100余篇，其中SCI论文75篇，发表通讯作者及第一单位共同通讯作者SCI论文60余篇，影响因子累计160余分。引用频次1200余次其中他引1100余次，单篇最高引频200余次。

代表性论文：

1. Hu MY#, Zhang P#, Leng M, Li C, Chen L*. Animal-assisted intervention for individuals with cognitive impairment: a meta-analysis of randomized controlled trials and quasi-randomized controlled trials[J]. Psychiatry research, 2018, 260: 418-427.

2. Jia Yong, Li Feng, Liu Yufei, Zhao Jinping, Leng Minmin, Chen Li*. Depression and cancer risk: a systematic review and meta-analysis[J].Public health,2017 ,149:138-148.

3. Chen Li#, Duo Xu#, Mingyue Hu, Yongfei Tan, Ping Zhang, Guichen Li, Li Chen*. A systematic review and meta-analysis of randomized controlled trials of cognitive behavior therapy for patients with diabetes and depression[J]. Journal of Psychosomatic Research, 2017,95:44-54.

4. 李晨,白越,胡明月,陈立*.网络认知行为疗法在精神障碍患者中的研究现状[J].护理学杂志,2017, 32(11): 101-104.

5. 华珊珊,李闺臣,彩虹,刘宇飞,陈立*.运动疗法对糖尿病周围神经病变影响的研究进展[J].中华护理杂志,2017,52(10):1252-1256.

6. 华珊珊,陈立,彩虹,刘延迪,李菲*.2型糖尿病患者慢性甲醇中毒的护理[J].护理学杂志,2017,32(07):28-30.

7. Hong Cai#, Guichen Li#, Shanshan Hua, Yufei Liu, Li Chen*. Effect of exercise on cognitive function in chronic disease patients: a meta-analysis and systematic review of randomized controlled trials[J]. Clinical Interventions in Aging, 2017:12 773–783.

8. Hong Cai#, Guichen Li#, Ping Zhang, Duo Xu, Li Chen*. Effect of exercise on the quality of life in type 2 diabetes mellitus: a systematic review [J]. Quality of Life Research, 2017:26 .515-530.

9. Hu MY#, Zhang P#, Li C, Tan YY, Li GC, Xu D, Chen L *. Sleep disturbance in mild cognitive impairment: a systematic review of objective measures[J]. Neurological Sciences, 2017, 38(8): 1363-1371.

10. 胡明月#,张萍,李晨,华珊珊，彩虹，陈立*.轻度认知障碍患者体内微量元素Cu和Zn含量的Meta分析[J].现代预防医学, 2017,44(6):1097-1101.

11. 冷敏敏,张萍,胡明月,陈立*.玩偶疗法在痴呆患者护理中的应用进展[J].中华护理杂志, 2017, 52(11): 1322-1326.

12. 赵金萍,李晨,许多,陈立*.对癌症患者实施网络干预的研究进展[J].中华护理杂志,2017,52(11):1375-1378.

13. 华珊珊,陈立,李菲,彩虹,胡明月,李晨,李闺臣*.儿童饮水现状及脱水对其认知功能影响的研究进展[J].护理学杂志,2016,31(23):102-105.

14. Zhao Y, Cui L, Pan Y, Shao D, Zheng X, Zhang F, Zhang H, He K, Chen L. Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer.Cell Prolif. 2017 Dec;50(6).

15. Chang W(#), Zhang M, Chen L, Hatch GM*. Berberine Inhibits Oxygen Consumption Rate Independent of Alteration in Cardiolipin Levels in H9c2 Cells. Lipids. 2017 Sep 23. doi: 10.1007/s11745-017-4300-z.

16. Pan Y(#), Zhang F, Zhao Y, Shao D, Zheng X, Chen Y, He K, Li J, Chen L*. Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer. J Cancer. 2017 Jun 5;8(9):1679-1689.

17. Yu Y(#), Feng L, Li J, Lan X, A L, Lv X, Zhang M*, Chen L. The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits.Behav Brain Res. 2017 Sep 15;334:155-162.

18. Yao F(#), Chen L, Fan Z, Teng F, Zhao Y, Guan F, Zhang M*, Liu Y. Interplay between H6PDH and 11β-HSD1 implicated in the pathogenesis of type 2 diabetes mellitus.Bioorg Med Chem Lett. 2017 Sep 1;27(17):4107-4113.

19. Shao D, Lu M, Xu D, Zheng X, Pan Y, Song Y, Xu J, Li M, Zhang M, Li J, Chi G*, Chen L*, Yang B. Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells.Biomater Sci. 2017 Aug 22;5(9):1820-1827.

20. Pan Y, Shao D, Zhao Y, Zhang F, Zheng X, Tan Y, He K, Li J, Chen L*. Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α. Int J Biol Sci. 2017 Jun 1;13(6):794-803.

21. Yao F(#), Zhang M, Chen L*. Adipose Tissue-Specialized Immunologic Features Might Be the Potential Therapeutic Target of Prospective Medicines for Obesity. J Diabetes Res. 2017;2017:4504612.

22. Yao F(#), Yu Y, Feng L, Li J, Zhang M, Lan X, Yan X, Liu Y, Guan F, Zhang M*, Chen L*. Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγof insulin resistance induced by high-fat diet-associated obesity. Exp Cell Res. 2017 Jun 15;355(2):105-112.

23. Shao D(#), Lu MM, Zhao YW, Zhang F, Tan YF, Zheng X, Pan Y, Xiao XA, Wang Z, Dong WF, Li J, Chen L. The shape effect of magnetic mesoporous silica nanoparticles on endocytosis, biocompatibility and biodistribution. Acta Biomater. 2017 Feb;49:531-540.

24. Jin Y, Liu S, Ma Q, Xiao D, Chen L*. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes. Eur J Pharmacol. 2017 Jan 5;794:106-114.

25. Wei S(#),, Zhang M(#), Yu Y, Xue H, Lan X, Liu S, Hatch G, Chen L*. HNF-4aregulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells. Eur J Pharmacol. 2016 Nov 15;791:254-263.

26. Shao D(#),Li J(#), Zheng X, Pan Y, Wang Z, Zhang M, Chen QX, Dong WF, Chen L*. Janus "nano-bullets" for magnetic targeting liver cancer chemotherapy.Biomaterials. 2016 Sep;100:118-33.

27. Xue H(#), Ji Y(#), Wei S, Yu Y, Yan X, Liu S, Zhang M, Yao F, Lan X, Chen L*. HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: The role of AMP-activated protein kinase. Life Sci. 2016 May 15;153:23-34.

28. Zhang M, Feng LJ, Li JN, Chen L*. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease. Curr Pharmacol Rep 2016;2:281-292.

29. Chen W(#),Wei S(#), Yu Y, Xue H, Yao F, Zhang M*, Xiao J*, Hatch GM, Chen L. Pretreatment of rats with increased bioavailable berberine attenuates cerebral ischemia-reperfusion injury via down regulation of adenosine-5'monophosphate kinase activity. Eur J Pharmacol. 2016 May 15;779:80-90.

30. Wei S(#), Zhang M(#), Yu Y, Lan X, Yao F, Yan X, Chen L*Hatch GM. Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4amiR122 Pathway.PLoS One. 2016 Mar 24;11(3):e0152097.

31. Yao F#, Zhang M, Chen L*. 5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications. Acta Pharm Sin B. 2016 Jan;6(1):20-5.

32. Chang W, Li K, Guan F, Yao F, Yu Y, Zhang M*, Hatch GM, Chen L.Berberine Pretreatment Confers Cardioprotection Against Ischemia-Reperfusion Injury in a Rat Model of Type 2 Diabetes.J Cardiovasc Pharmacol Ther. 2016 Feb 4.

33. Shao D, Wang Z, Dong WF, Zhang X, Zheng X, Xiao XA, Wang YS, Zhao X, Zhang M, Li J, Huo QS, Chen L. Facile Synthesis of Core-shell Magnetic Mesoporous Silica Nanoparticles for pH-sensitive Anticancer Drug Delivery. Chem Biol Drug Des. 2015 Dec;86(6):1548-53.

34. Xiao Zheng, Dan Shao, Jing Li, Yubin Song, Yujing Chen, Yue Pan, Shoujun Zhu, Bai Yang and Li Chen. Single and repeated dose toxicity of citric acid-based carbon dots and a derivative in mice. RSC Adv., 2015, 5, 91398-91406.

35. Chang W(#), Zhang M(#), Meng Z, Yu Y, Yao F, Hatch GM, Chen L*. Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5'-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells. Eur J Pharmacol. 2015 Dec 15;769:55-63.

36. Wei S, Li W, Yu Y, Yao F, A L, Lan X, Guan F, Zhang M*, Chen L*Ginsenoside Compound K suppresses the hepatic gluconeogenesis via activating adenosine-5'monophosphate kinase: A study in vitro and in vivo.Life Sci. 2015 Oct 15;139:8-15

37. Li J (#), Li O(#), Kan M, Zhang M, Shao D, Pan Y, Zheng H, Zhang X*, Chen L*, Liu S. Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma. Mol Med Rep. 2015 Sep;12(3):4572-7.

38. Dan Shao (#), Jing Li (#), Yue Pan, Xin Zhang, Xiao Zheng, Zheng Wang, Ming Zhang, Hong Zhang* and Li Chen* Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate targeted quantum dot-based liposomes. Biomater Sci. 2015 Jun 19;3(6):833-41.

39. Sun B, Li J(#), Shao D, Pan Y, Chen Y, Li S, Yao X, Li H, Liu W, Zhang M, Zhang X*, Chen L*. Adipose tissue-secreted miR-27a promotes liver cancer by targeting FOXO1 in obese individuals.Onco Targets Ther. 2015 Apr 7;8:735-44.

40. Yue Pan, Zheng Wang,Dan Shao, Huilin Zheng, Yujing Chen, Xiao Zheng, Ming Zhang,Jing Li,* Feng Li, Li Chen*. CTAB induced mitochondrial apoptosis by activating the AMPK–p53 pathway in hepatocarcinoma cells. Toxicol. Res. , 2015, 4,1359.

41. Li S, Li J, Fei BY, Shao D, Pan Y, Mo ZH, Sun BZ, Zhang D, Zheng X, Zhang M, Zhang XW, Chen L.MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ.Chin Med J (Engl). 2015 5th Apr;128(7):941-947.

代表性项目：

国家自然科学基金资助面上项目 2016.1-2019.12 81570762 62.4万

课题名称：miR27a作为巨噬细胞活化以及脂肪前体细胞重编程调控靶点在肥胖诱导胰岛素抵抗中的作用

省科技厅吉林省医药产业发展引导资金项目 2015.1-2017.12 20150311013YY 50万

课题名称：黄癸固体分散体肠溶胶囊剂生物基囊壳的研究和开发

吉林省科技发展计划项目重大科技攻关专项 2014.1-2016.12 20140203011YY 50万

课题名称：黄连素抗糖尿病新适应症的研究与开发

国家自然科学基金资助面上项目 2014.1-2017.12 81371681 70 70万

课题名称：多功能磁-介孔二氧化硅纳米复合载体系统抗肝癌复发及机制研究

国家自然科学基金资助面上项目 2012.1-2015.12 81170745 50万